Glycemic Control, Cardiac Autoimmunity, and Long-Term Risk of Cardiovascular Disease in Type 1 Diabetes Mellitus | Zendy

Giovane Rodrigo Sousa | Zendy; David Pober | Zendy; Alfonso Galderisi | Zendy; Huijuan Lv | Zendy; Liping Yu | Zendy; Alexandre C. Pereira | Zendy; Alessandro Doria | Zendy; Mikhail Kosiborod | Zendy; Myra A. Lipes | Zendy

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Glycemic Control, Cardiac Autoimmunity, and Long-Term Risk of Cardiovascular Disease in Type 1 Diabetes Mellitus

Author(s) -

Giovane Rodrigo Sousa,

David Pober,

Alfonso Galderisi,

Huijuan Lv,

Liping Yu,

Alexandre C. Pereira,

Alessandro Doria,

Mikhail Kosiborod,

Myra A. Lipes

Publication year - 2019

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.118.036068

Subject(s) - medicine , diabetes mellitus , type 1 diabetes , myocardial infarction , cardiology , coronary artery disease , autoimmunity , glycemic , diabetic cardiomyopathy , cardiomyopathy , heart failure , disease , endocrinology

Poor glycemic control is associated with increased risk of cardiovascular disease (CVD) in type 1 diabetes mellitus (T1DM); however, little is known about mechanisms specific to T1DM. In T1DM, myocardial injury can induce persistent cardiac autoimmunity. Chronic hyperglycemia causes myocardial injury, raising the possibility that hyperglycemia-induced cardiac autoimmunity could contribute to long-term CVD complications in T1DM.

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