Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration | Zendy

Qin Fan | Zendy; Rong Tao | Zendy; Hang Zhang | Zendy; Hongyang Xie | Zendy; Lin Lu | Zendy; Ting Wang | Zendy; Min Su | Zendy; Jian Hu | Zendy; Qi Zhang | Zendy; Qiujing Chen | Zendy; Yoichiro Iwakura | Zendy; Weifeng Shen | Zendy; Ruiyan Zhang | Zendy; Xiaoxiang Yan | Zendy

Open Access

Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration

Author(s) -

Qin Fan,

Rong Tao,

Hang Zhang,

Hongyang Xie,

Lin Lu,

Ting Wang,

Min Su,

Jian Hu,

Qi Zhang,

Qiujing Chen,

Yoichiro Iwakura,

Weifeng Shen,

Ruiyan Zhang,

Xiaoxiang Yan

Publication year - 2019

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.118.036044

Subject(s) - medicine , immune system , inflammation , immunology , bone marrow , tumor necrosis factor alpha , monocyte , cancer research

Macrophage-associated immune response plays an important role in myocardial ischemia/reperfusion (IR) injury. Dectin-1, expressed mainly on activated myeloid cells, is crucial for the regulation of immune homeostasis as a pattern recognition receptor. However, its effects and roles during the myocardial IR injury remain unknown.

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