Evaluation of Microvascular Injury in Revascularized Patients With ST-Segment–Elevation Myocardial Infarction Treated With Ticagrelor Versus Prasugrel | Zendy

Maarten A.H. van Leeuwen | Zendy; Nina W. van der Hoeven | Zendy; Gladys N. Janssens | Zendy; Henk Everaars | Zendy; Alexander Nap | Zendy; Jorrit S. Lemkes | Zendy; Guus A. de Waard | Zendy; Peter M. van de Ven | Zendy; Albert C. van Rossum | Zendy; Tim J.F. ten Cate | Zendy; Jan J. Piek | Zendy; Clemens von Birgelen | Zendy; Javier Escaned | Zendy; Marco Valgimigli | Zendy; Roberto Diletti | Zendy; Niels P. Riksen | Zendy; Nicolas M. Van Mieghem | Zendy; Robin Nijveldt | Zendy; Niels van Royen | Zendy

Open Access

Evaluation of Microvascular Injury in Revascularized Patients With ST-Segment–Elevation Myocardial Infarction Treated With Ticagrelor Versus Prasugrel

Author(s) -

Maarten A.H. van Leeuwen,

Nina W. van der Hoeven,

Gladys N. Janssens,

Henk Everaars,

Alexander Nap,

Jorrit S. Lemkes,

Guus A. de Waard,

Peter M. van de Ven,

Albert C. van Rossum,

Tim J.F. ten Cate,

Jan J. Piek,

Clemens von Birgelen,

Javier Escaned,

Marco Valgimigli,

Roberto Diletti,

Niels P. Riksen,

Nicolas M. Van Mieghem,

Robin Nijveldt,

Niels van Royen

Publication year - 2019

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.118.035931

Subject(s) - ticagrelor , prasugrel , medicine , interquartile range , cardiology , myocardial infarction , percutaneous coronary intervention

Despite successful restoration of epicardial vessel patency with primary percutaneous coronary intervention, coronary microvascular injury occurs in a large proportion of patients with ST-segment-elevation myocardial infarction, adversely affecting clinical and functional outcome. Ticagrelor has been reported to increase plasma adenosine levels, which might have a protective effect on the microcirculation. We investigated whether ticagrelor maintenance therapy after revascularized ST-segment-elevation myocardial infarction is associated with less coronary microvascular injury compared to prasugrel maintenance therapy.

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