Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis | Zendy

Scott D. Solomon | Zendy; David Adams | Zendy; Arnt V. Kristen | Zendy; Martha Grogan | Zendy; Alejandra GonzálezDuarte | Zendy; Mathew S. Maurer | Zendy; Giampaolo Merlini | Zendy; Thibaud Damy | Zendy; Michel Slama | Zendy; Thomas H. Brannagan | Zendy; Angela Dispenzieri | Zendy; John L. Berk | Zendy; Amil M. Shah | Zendy; Pushkal Garg | Zendy; Akshay Vaishnaw | Zendy; Verena Karsten | Zendy; Jihong Chen | Zendy; Jared Gollob | Zendy; Joshua R. Vest | Zendy; Ole B. Suhr | Zendy

Open Access

Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis

Author(s) -

Scott D. Solomon,

David Adams,

Arnt V. Kristen,

Martha Grogan,

Alejandra GonzálezDuarte,

Mathew S. Maurer,

Giampaolo Merlini,

Thibaud Damy,

Michel Slama,

Thomas H. Brannagan,

Angela Dispenzieri,

John L. Berk,

Amil M. Shah,

Pushkal Garg,

Akshay Vaishnaw,

Verena Karsten,

Jihong Chen,

Jared Gollob,

Joshua R. Vest,

Ole B. Suhr

Publication year - 2019

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.118.035831

Subject(s) - medicine , cardiac amyloidosis , cardiology , placebo , amyloidosis , population , cardiomyopathy , interventricular septum , heart failure , ventricle , pathology , alternative medicine , environmental health

Hereditary transthyretin-mediated (hATTR) amyloidosis is a rapidly progressive, multisystem disease that presents with cardiomyopathy or polyneuropathy. The APOLLO study assessed the efficacy and tolerability of patisiran in patients with hATTR amyloidosis. The effects of patisiran on cardiac structure and function in a prespecified subpopulation of patients with evidence of cardiac amyloid involvement at baseline were assessed.

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