Small GTP-Binding Protein GDP Dissociation Stimulator Prevents Thoracic Aortic Aneurysm Formation and Rupture by Phenotypic Preservation of Aortic Smooth Muscle Cells | Zendy

Masamichi Nogi | Zendy; Kimio Satoh | Zendy; Shinichiro Sunamura | Zendy; Nobuhiro Kikuchi | Zendy; Taijyu Satoh | Zendy; Ryo Kurosawa | Zendy; Junichi Omura | Zendy; Md. Elias-Al-Mamun | Zendy; Mohammad Abdul Hai Siddique | Zendy; Kazuhiko Numano | Zendy; Shun Kudo | Zendy; Satoshi Miyata | Zendy; Masatoshi Akiyama | Zendy; Kiichiro Kumagai | Zendy; Shunsuke Kawamoto | Zendy; Yoshikatsu Saiki | Zendy; Hiroaki Shimokawa | Zendy

Open Access

Small GTP-Binding Protein GDP Dissociation Stimulator Prevents Thoracic Aortic Aneurysm Formation and Rupture by Phenotypic Preservation of Aortic Smooth Muscle Cells

Author(s) -

Masamichi Nogi,

Kimio Satoh,

Shinichiro Sunamura,

Nobuhiro Kikuchi,

Taijyu Satoh,

Ryo Kurosawa,

Junichi Omura,

Md. Elias-Al-Mamun,

Mohammad Abdul Hai Siddique,

Kazuhiko Numano,

Shun Kudo,

Satoshi Miyata,

Masatoshi Akiyama,

Kiichiro Kumagai,

Shunsuke Kawamoto,

Yoshikatsu Saiki,

Hiroaki Shimokawa

Publication year - 2018

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.118.035648

Subject(s) - medicine , angiotensin ii , apolipoprotein e , ascending aorta , aortic aneurysm , aorta , thoracic aortic aneurysm , aortic dissection , aortic rupture , thoracic aorta , aneurysm , abdominal aortic aneurysm , cardiology , surgery , receptor , disease

Thoracic aortic aneurysm (TAA) and dissection are fatal diseases that cause aortic rupture and sudden death. The small GTP-binding protein GDP dissociation stimulator (SmgGDS) is a crucial mediator of the pleiotropic effects of statins. Previous studies revealed that reduced force generation in aortic smooth muscle cells (AoSMCs) causes TAA and thoracic aortic dissection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research