Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels | Zendy

Maria SabaterLleal | Zendy; Jennifer E. Huffman | Zendy; Paul S. de Vries | Zendy; Jonathan Marten | Zendy; Michael A. Mastrangelo | Zendy; Ci Song | Zendy; Nathan Pankratz | Zendy; Cavin WardCaviness | Zendy; Lisa R. Yanek | Zendy; Stella Trompet | Zendy; Graciela E. Delgado | Zendy; Xiuqing Guo | Zendy; Traci M. Bartz | Zendy; Ángel Martínez-Pérez | Zendy; Marine Germain | Zendy; Hugoline G. de Haan | Zendy; Ayse Bilge Ozel | Zendy; Ozren Polašek | Zendy; Albert V. Smith | Zendy; John D. Eicher | Zendy; Alex P. Reiner | Zendy; Weihong Tang | Zendy; Neil M Davies | Zendy; David J. Stott | Zendy; Jerome I. Rotter | Zendy; Geoffrey H. Tofler | Zendy; Eric Boerwinkle | Zendy; Moniek P.M. de Maat | Zendy; Marcus E. Kleber | Zendy; Paul Welsh | Zendy; Jennifer A. Brody | Zendy; MingHuei Chen | Zendy; Dhananjay Vaidya | Zendy; José Manuel Soria | Zendy; Pierre Suchon | Zendy; Astrid van Hylckama Vlieg | Zendy; Karl C. Desch | Zendy; Ivana Kolčić | Zendy; Peter K. Joshi | Zendy; Lenore J. Launer | Zendy; Tamara B. Harris | Zendy; Harry Campbell | Zendy; Igor Rudan | Zendy; Diane M. Becker | Zendy; Jun Z. Li | Zendy; Fernando Rivadeneira | Zendy; André G. Uitterlinden | Zendy; Albert Hofman | Zendy; Oscar H. Franco | Zendy; Mary Cushman | Zendy; Bruce M. Psaty | Zendy; PierreEmmanuel Morange | Zendy; Barbara McKnight | Zendy; Michael Chong | Zendy; Israel FernándezCadenas | Zendy; Jonathan Rosand | Zendy; Cecilia M. Lindgren | Zendy; Vilmundur Guðnason | Zendy; James F. Wilson | Zendy; Caroline Hayward | Zendy; David Ginsburg | Zendy; Myriam Fornage | Zendy; Frits R. Rosendaal | Zendy; Juan Carlos Souto | Zendy; Lewis C. Becker | Zendy; Nancy S. Jenny | Zendy; Winfried März | Zendy; J. Wouter Jukema | Zendy; Abbas Dehghan | Zendy; DavidAlexandre Trégouët | Zendy; Alanna C. Morrison | Zendy; Andrew D. Johnson | Zendy; Christopher J. O’Donnell | Zendy; David P. Strachan | Zendy; Charles J. Lowenstein | Zendy; Nicholas L. Smith | Zendy

Open Access

Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels

Author(s) -

Maria SabaterLleal,

Jennifer E. Huffman,

Paul S. de Vries,

Jonathan Marten,

Michael A. Mastrangelo,

Ci Song,

Nathan Pankratz,

Cavin WardCaviness,

Lisa R. Yanek,

Stella Trompet,

Graciela E. Delgado,

Xiuqing Guo,

Traci M. Bartz,

Ángel Martínez-Pérez,

Marine Germain,

Hugoline G. de Haan,

Ayse Bilge Ozel,

Ozren Polašek,

Albert V. Smith,

John D. Eicher,

Alex P. Reiner,

Weihong Tang,

Neil M Davies,

David J. Stott,

Jerome I. Rotter,

Geoffrey H. Tofler,

Eric Boerwinkle,

Moniek P.M. de Maat,

Marcus E. Kleber,

Paul Welsh,

Jennifer A. Brody,

MingHuei Chen,

Dhananjay Vaidya,

José Manuel Soria,

Pierre Suchon,

Astrid van Hylckama Vlieg,

Karl C. Desch,

Ivana Kolčić,

Peter K. Joshi,

Lenore J. Launer,

Tamara B. Harris,

Harry Campbell,

Igor Rudan,

Diane M. Becker,

Jun Z. Li,

Fernando Rivadeneira,

André G. Uitterlinden,

Albert Hofman,

Oscar H. Franco,

Mary Cushman,

Bruce M. Psaty,

PierreEmmanuel Morange,

Barbara McKnight,

Michael Chong,

Israel FernándezCadenas,

Jonathan Rosand,

Cecilia M. Lindgren,

Vilmundur Guðnason,

James F. Wilson,

Caroline Hayward,

David Ginsburg,

Myriam Fornage,

Frits R. Rosendaal,

Juan Carlos Souto,

Lewis C. Becker,

Nancy S. Jenny,

Winfried März,

J. Wouter Jukema,

Abbas Dehghan,

DavidAlexandre Trégouët,

Alanna C. Morrison,

Andrew D. Johnson,

Christopher J. O’Donnell,

David P. Strachan,

Charles J. Lowenstein,

Nicholas L. Smith

Publication year - 2019

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.118.034532

Subject(s) - mendelian randomization , von willebrand factor , genome wide association study , medicine , genetic association , von willebrand disease , genetics , single nucleotide polymorphism , gene , immunology , bioinformatics , genotype , biology , platelet , genetic variants

Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associations regulating plasma FVIII and VWF.

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