An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels | Zendy

May E. Montasser | Zendy; Elizabeth A. O’Hare | Zendy; Xiaochun Wang | Zendy; Alicia Howard | Zendy; Rebecca McFarland | Zendy; James A. Perry | Zendy; Kathleen A. Ryan | Zendy; Kenneth Rice | Zendy; Cashell E. Jaquish | Zendy; Alan R. Shuldiner | Zendy; Michael Miller | Zendy; Braxton D. Mitchell | Zendy; Norann A. Zaghloul | Zendy; Yen-Pei C. Chang | Zendy

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An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels

Author(s) -

May E. Montasser,

Elizabeth A. O’Hare,

Xiaochun Wang,

Alicia Howard,

Rebecca McFarland,

James A. Perry,

Kathleen A. Ryan,

Kenneth Rice,

Cashell E. Jaquish,

Alan R. Shuldiner,

Michael Miller,

Braxton D. Mitchell,

Norann A. Zaghloul,

Yen-Pei C. Chang

Publication year - 2018

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.118.034016

Subject(s) - medicine , pseudogene , cholesterol , chromosome , genetics , lipoprotein , endocrinology , gene , genome , biology

Elevated levels of low-density lipoprotein cholesterol (LDL-C) are a major risk factor for cardiovascular disease via its contribution to the development and progression of atherosclerotic lesions. Although the genetic basis of LDL-C has been studied extensively, currently known genetic variants account for only ≈20% of the variation in LDL-C levels.

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