Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension | Zendy

Aurélie Hautefort | Zendy; Pedro MendesFerreira | Zendy; Jessica Sabourin | Zendy; Grégoire Manaud | Zendy; Thomas Bertero | Zendy; Catherine RückerMartin | Zendy; Marianne Riou | Zendy; Rui Adão | Zendy; Boris Manoury | Zendy; Mélanie Lambert | Zendy; Angèle Boët | Zendy; Florence Lecerf | Zendy; Valérie Domergue | Zendy; Carmen BrásSilva | Zendy; Ana M. Gómez | Zendy; David Montani | Zendy; Barbara Girerd | Zendy; Marc Humbert | Zendy; Fabrice Antigny | Zendy; Frédéric Perros | Zendy

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Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension

Author(s) -

Aurélie Hautefort,

Pedro MendesFerreira,

Jessica Sabourin,

Grégoire Manaud,

Thomas Bertero,

Catherine RückerMartin,

Marianne Riou,

Rui Adão,

Boris Manoury,

Mélanie Lambert,

Angèle Boët,

Florence Lecerf,

Valérie Domergue,

Carmen BrásSilva,

Ana M. Gómez,

David Montani,

Barbara Girerd,

Marc Humbert,

Fabrice Antigny,

Frédéric Perros

Publication year - 2019

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.118.033744

Subject(s) - bmpr2 , medicine , pulmonary hypertension , penetrance , endocrinology , pulmonary artery , ventricle , pathology , gene , phenotype , biology , genetics , bone morphogenetic protein

Monoallelic mutations in the gene encoding bone morphogenetic protein receptor 2 ( Bmpr2) are the main genetic risk factor for heritable pulmonary arterial hypertension (PAH) with incomplete penetrance. Several Bmpr2 transgenic mice have been reported to develop mild spontaneous PAH. In this study, we examined whether rats with the Bmpr2 mutation were susceptible to developing more severe PAH.

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