Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension | Zendy

Nobuhiro Kikuchi | Zendy; Kimio Satoh | Zendy; Ryo Kurosawa | Zendy; Nobuhiro Yaoita | Zendy; Md. Elias-Al-Mamun | Zendy; Mohammad Abdul Hai Siddique | Zendy; Junichi Omura | Zendy; Taijyu Satoh | Zendy; Masamichi Nogi | Zendy; Shinichiro Sunamura | Zendy; Satoshi Miyata | Zendy; Yoshiro Saito | Zendy; Yasushi Hoshikawa | Zendy; Yoshinori Okada | Zendy; Hiroaki Shimokawa | Zendy

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Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension

Author(s) -

Nobuhiro Kikuchi,

Kimio Satoh,

Ryo Kurosawa,

Nobuhiro Yaoita,

Md. Elias-Al-Mamun,

Mohammad Abdul Hai Siddique,

Junichi Omura,

Taijyu Satoh,

Masamichi Nogi,

Shinichiro Sunamura,

Satoshi Miyata,

Yoshiro Saito,

Yasushi Hoshikawa,

Yoshinori Okada,

Hiroaki Shimokawa

Publication year - 2018

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.117.033113

Subject(s) - medicine , hypoxia (environmental) , pulmonary hypertension , pulmonary artery , knockout mouse , right ventricular hypertrophy , biomarker , muscle hypertrophy , pathology , endocrinology , cardiology , receptor , chemistry , oxygen , biochemistry , organic chemistry

Excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs) are key mechanisms of pulmonary arterial hypertension (PAH). Despite the multiple combination therapy, a considerable number of patients develop severe pulmonary hypertension (PH) because of the lack of diagnostic biomarker and antiproliferative therapies for PASMCs.

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