Comparison of Reduced-Dose Prasugrel and Standard-Dose Clopidogrel in Elderly Patients With Acute Coronary Syndromes Undergoing Early Percutaneous Revascularization | Zendy

Stefano Savonitto | Zendy; Luca Ferri | Zendy; Luigi Piatti | Zendy; Daniele Grosseto | Zendy; Giancarlo Piovaccari | Zendy; Nuccia Morici | Zendy; Irene Bossi | Zendy; Paolo Sganzerla | Zendy; Giovanni Tortorella | Zendy; Michele Cacucci | Zendy; Maurizio Ferrario | Zendy; Ernesto Murena | Zendy; Girolamo Sibilio | Zendy; Stefano Tondi | Zendy; Anna Toso | Zendy; Sergio Bongioanni | Zendy; Amelia Ravera | Zendy; Elena Corrada | Zendy; Matteo Mariani | Zendy; Leonardo Di Ascenzo | Zendy; Anna Sonia Petronio | Zendy; Claudio Cavallini | Zendy; Giancarlo Vitrella | Zendy; Renata Rogacka | Zendy; Roberto Antonicelli | Zendy; Bruno Mario Cesana | Zendy; Leonardo De Luca | Zendy; Filippo Ottani | Zendy; Giuseppe De Luca | Zendy; Federico Piscione | Zendy; Nadia Moffa | Zendy; Stefano De Servi | Zendy; Leonardo Bolognese | Zendy; Francesco Bovenzi | Zendy; Giuseppe Steffenino | Zendy; Ignazio Santilli | Zendy; Giorgio Bassanelli | Zendy; Alice Sacco | Zendy; Federico Canziani | Zendy; Marco Ferri | Zendy; Emilia Lo Jacono | Zendy; Umberto Canosi | Zendy; Giuseppe Fornaro | Zendy; Mario Leoncini | Zendy; Maria Rosa Conte | Zendy; Rosario Farina | Zendy; Catia Stefanin | Zendy; Francesco Di Pede | Zendy; Piersilvio Chella | Zendy; M. Chiara Nardoni | Zendy; Paola Tamburrini | Zendy; Bruno Trimarco | Zendy; Gennaro Galasso | Zendy; Raffaele Elia | Zendy; Simone Grotti | Zendy; Lucia Borrelli | Zendy; Corrado Tamburino | Zendy; Piera Capranzano | Zendy; Bruno Francaviglia | Zendy; Carlo Campana | Zendy; Roberto Bonatti | Zendy; Alessandro Martii | Zendy; Fabio Abate | Zendy; Sebastian Coscarelli | Zendy; Paolo Rubartelli | Zendy; Giovanni Villani | Zendy; Roberta Rossini | Zendy

Open Access

Comparison of Reduced-Dose Prasugrel and Standard-Dose Clopidogrel in Elderly Patients With Acute Coronary Syndromes Undergoing Early Percutaneous Revascularization

Author(s) -

Stefano Savonitto,

Luca Ferri,

Luigi Piatti,

Daniele Grosseto,

Giancarlo Piovaccari,

Nuccia Morici,

Irene Bossi,

Paolo Sganzerla,

Giovanni Tortorella,

Michele Cacucci,

Maurizio Ferrario,

Ernesto Murena,

Girolamo Sibilio,

Stefano Tondi,

Anna Toso,

Sergio Bongioanni,

Amelia Ravera,

Elena Corrada,

Matteo Mariani,

Leonardo Di Ascenzo,

Anna Sonia Petronio,

Claudio Cavallini,

Giancarlo Vitrella,

Renata Rogacka,

Roberto Antonicelli,

Bruno Mario Cesana,

Leonardo De Luca,

Filippo Ottani,

Giuseppe De Luca,

Federico Piscione,

Nadia Moffa,

Stefano De Servi,

Leonardo Bolognese,

Francesco Bovenzi,

Giuseppe Steffenino,

Ignazio Santilli,

Giorgio Bassanelli,

Alice Sacco,

Federico Canziani,

Marco Ferri,

Emilia Lo Jacono,

Umberto Canosi,

Giuseppe Fornaro,

Mario Leoncini,

Maria Rosa Conte,

Rosario Farina,

Catia Stefanin,

Francesco Di Pede,

Piersilvio Chella,

M. Chiara Nardoni,

Paola Tamburrini,

Bruno Trimarco,

Gennaro Galasso,

Raffaele Elia,

Simone Grotti,

Lucia Borrelli,

Corrado Tamburino,

Piera Capranzano,

Bruno Francaviglia,

Carlo Campana,

Roberto Bonatti,

Alessandro Martii,

Fabio Abate,

Sebastian Coscarelli,

Paolo Rubartelli,

Giovanni Villani,

Roberta Rossini

Publication year - 2018

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.117.032180

Subject(s) - medicine , prasugrel , clopidogrel , revascularization , cardiology , ticagrelor , percutaneous coronary intervention , percutaneous , anesthesia , myocardial infarction

Elderly patients are at elevated risk of both ischemic and bleeding complications after an acute coronary syndrome and display higher on-clopidogrel platelet reactivity compared with younger patients. Prasugrel 5 mg provides more predictable platelet inhibition compared with clopidogrel in the elderly, suggesting the possibility of reducing ischemic events without increasing bleeding.

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