Histone Methyltransferase G9a Is Required for Cardiomyocyte Homeostasis and Hypertrophy | Zendy

Roberto Papait | Zendy; Simone Serio | Zendy; Christina Pagiatakis | Zendy; Francesca Rusconi | Zendy; Pierluigi Carullo | Zendy; Marta Mazzola | Zendy; Nicolò Salvarani | Zendy; Michele Miragoli | Zendy; Gianluigi Condorelli | Zendy

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Histone Methyltransferase G9a Is Required for Cardiomyocyte Homeostasis and Hypertrophy

Author(s) -

Roberto Papait,

Simone Serio,

Christina Pagiatakis,

Francesca Rusconi,

Pierluigi Carullo,

Marta Mazzola,

Nicolò Salvarani,

Michele Miragoli,

Gianluigi Condorelli

Publication year - 2017

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.117.028561

Subject(s) - epigenetics , biology , epigenome , mef2c , histone methyltransferase , histone , chromatin , histone h3 , chromatin immunoprecipitation , epigenomics , microbiology and biotechnology , methyltransferase , transcription factor , gene expression , genetics , gene , promoter , dna methylation , methylation

Correct gene expression programming of the cardiomyocyte underlies the normal functioning of the heart. Alterations to this can lead to the loss of cardiac homeostasis, triggering heart dysfunction. Although the role of some histone methyltransferases in establishing the transcriptional program of postnatal cardiomyocytes during heart development has been shown, the function of this class of epigenetic enzymes is largely unexplored in the adult heart. In this study, we investigated the role of G9a/Ehmt2, a histone methyltransferase that defines a repressive epigenetic signature, in defining the transcriptional program for cardiomyocyte homeostasis and cardiac hypertrophy.

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