The Optimal Timing of Stage 2 Palliation for Hypoplastic Left Heart Syndrome | Zendy

James M. Meza | Zendy; Edward Hickey | Zendy; Eugene H. Blackstone | Zendy; Robert D.B. Jaquiss | Zendy; Brett R. Anderson | Zendy; William G. Williams | Zendy; Sally Cai | Zendy; Glen S. Van Arsdell | Zendy; Tara Karamlou | Zendy; Brian W. McCrindle | Zendy

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The Optimal Timing of Stage 2 Palliation for Hypoplastic Left Heart Syndrome

Author(s) -

James M. Meza,

Edward Hickey,

Eugene H. Blackstone,

Robert D.B. Jaquiss,

Brett R. Anderson,

William G. Williams,

Sally Cai,

Glen S. Van Arsdell,

Tara Karamlou,

Brian W. McCrindle

Publication year - 2017

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.117.028481

Subject(s) - hypoplastic left heart syndrome , norwood procedure , medicine , interquartile range , heart transplantation , hazard ratio , survival analysis , cardiology , surgery , transplantation , heart disease , confidence interval

In infants requiring 3-stage single-ventricle palliation for hypoplastic left heart syndrome, attrition after the Norwood procedure remains significant. The effect of the timing of stage 2 palliation (S2P), a physician-modifiable factor, on long-term survival is not well understood. We hypothesized that an optimal interval between the Norwood and S2P that both minimizes pre-S2P attrition and maximizes post-S2P survival exists and is associated with individual patient characteristics.

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