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Tomo-Seq Identifies SOX9 as a Key Regulator of Cardiac Fibrosis During Ischemic Injury
Author(s) -
Grégory Lacraz,
Jan Philipp Junker,
Monika M Gladka,
Bas Molenaar,
Koen T. Scholman,
Marta VigilGarcia,
Daniëlle Versteeg,
Hesther de Ruiter,
Marit W. Vermunt,
Menno P. Creyghton,
Ma M. H. Huibers,
Nicolaas de Jonge,
Alexander van Oudenaarden,
Eva van Rooij
Publication year - 2017
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.117.027832
Subject(s) - fibrosis , transcriptome , heart failure , medicine , regulator , cardiac fibrosis , transcriptional regulation , gene , gene expression , biology , computational biology , bioinformatics , pathology , genetics
Cardiac ischemic injury induces a pathological remodeling response, which can ultimately lead to heart failure. Detailed mechanistic insights into molecular signaling pathways relevant for different aspects of cardiac remodeling will support the identification of novel therapeutic targets.

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