Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity | Zendy

Yvonne Döring | Zendy; Heidi Noels | Zendy; Emiel P. C. van der Vorst | Zendy; Carlos Neideck | Zendy; Virginia Egea | Zendy; Maik Drechsler | Zendy; Manuela Mandl | Zendy; Lukas Pawig | Zendy; Yvonne Jansen | Zendy; Katrin Schröder | Zendy; Kiril Bidzhekov | Zendy; Remco T. A. Megens | Zendy; Wendy Theelen | Zendy; Barbara M. Klinkhammer | Zendy; Peter Boor | Zendy; Leon J. Schurgers | Zendy; Rick van Gorp | Zendy; Christian Ries | Zendy; Pascal Kusters | Zendy; Allard C. van der Wal | Zendy; Tilman M. Hackeng | Zendy; Gábor Gäbel | Zendy; Ralf P. Brandes | Zendy; Oliver Soehnlein | Zendy; Esther Lutgens | Zendy; Dietmar Vestweber | Zendy; Daniel Teupser | Zendy; Lesca M. Holdt | Zendy; Daniel J. Rader | Zendy; Danish Saleheen | Zendy; Christian Weber | Zendy

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Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity

Author(s) -

Yvonne Döring,

Heidi Noels,

Emiel P. C. van der Vorst,

Carlos Neideck,

Virginia Egea,

Maik Drechsler,

Manuela Mandl,

Lukas Pawig,

Yvonne Jansen,

Katrin Schröder,

Kiril Bidzhekov,

Remco T. A. Megens,

Wendy Theelen,

Barbara M. Klinkhammer,

Peter Boor,

Leon J. Schurgers,

Rick van Gorp,

Christian Ries,

Pascal Kusters,

Allard C. van der Wal,

Tilman M. Hackeng,

Gábor Gäbel,

Ralf P. Brandes,

Oliver Soehnlein,

Esther Lutgens,

Dietmar Vestweber,

Daniel Teupser,

Lesca M. Holdt,

Daniel J. Rader,

Danish Saleheen,

Christian Weber

Publication year - 2017

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.117.027646

Subject(s) - medicine , wnt signaling pathway , endothelial stem cell , cxcr4 , progenitor cell , chemokine receptor , microbiology and biotechnology , chemokine , inflammation , immunology , biology , cancer research , signal transduction , stem cell , biochemistry , in vitro

The CXCL12/CXCR4 chemokine ligand/receptor axis controls (progenitor) cell homeostasis and trafficking. So far, an atheroprotective role of CXCL12/CXCR4 has only been implied through pharmacological intervention, in particular, because the somatic deletion of the CXCR4 gene in mice is embryonically lethal. Moreover, cell-specific effects of CXCR4 in the arterial wall and underlying mechanisms remain elusive, prompting us to investigate the relevance of CXCR4 in vascular cell types for atheroprotection.

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