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Thioredoxin (TRX)-1, a ubiquitous 12-kDa protein, exerts antioxidant and anti-inflammatory effects. In contrast, the truncated form, called TRX80, produced by macrophages induces upregulation of proinflammatory cytokines. TRX80 also promotes the differentiation of mouse peritoneal and human macrophages toward a proinflammatory M1 phenotype.

Human Plasma Thioredoxin-80 Increases With Age and in ApoE−/−Mice Induces Inflammation, Angiogenesis, and Atherosclerosis

Human Plasma Thioredoxin-80 Increases With Age and in ApoE^−/−Mice Induces Inflammation, Angiogenesis, and Atherosclerosis