Human Plasma Thioredoxin-80 Increases With Age and in ApoE −/− Mice Induces Inflammation, Angiogenesis, and Atherosclerosis | Zendy

Dominique Couchie | Zendy; Boris Vaisman | Zendy; Amna Abderrazak | Zendy; Dler Faieeq Darweesh Mahmood | Zendy; Magda M. Hamza | Zendy; Fanny Canesi | Zendy; Vimala Diderot | Zendy; Khadija El Hadri | Zendy; Anne NègreSalvayre | Zendy; Aurélie Le Page | Zendy; Tamás Fülöp | Zendy; Alan T. Remaley | Zendy; Mustapha Rouis | Zendy

Open Access

Human Plasma Thioredoxin-80 Increases With Age and in ApoE ^−/− Mice Induces Inflammation, Angiogenesis, and Atherosclerosis

Author(s) -

Dominique Couchie,

Boris Vaisman,

Amna Abderrazak,

Dler Faieeq Darweesh Mahmood,

Magda M. Hamza,

Fanny Canesi,

Vimala Diderot,

Khadija El Hadri,

Anne NègreSalvayre,

Aurélie Le Page,

Tamás Fülöp,

Alan T. Remaley,

Mustapha Rouis

Publication year - 2017

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.117.027612

Subject(s) - proinflammatory cytokine , angiogenesis , inflammation , microbiology and biotechnology , medicine , macrophage , cd163 , immunology , biology , cancer research , in vitro , biochemistry

Thioredoxin (TRX)-1, a ubiquitous 12-kDa protein, exerts antioxidant and anti-inflammatory effects. In contrast, the truncated form, called TRX80, produced by macrophages induces upregulation of proinflammatory cytokines. TRX80 also promotes the differentiation of mouse peritoneal and human macrophages toward a proinflammatory M1 phenotype.

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