Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus | Zendy

Caroline Dale | Zendy; Ghazaleh Fatemifar | Zendy; Tom Palmer | Zendy; Jon White | Zendy; David PrietoMerino | Zendy; Delilah Zabaneh | Zendy; Jorgen Engmann | Zendy; Tina Shah | Zendy; Andrew Wong | Zendy; Helen R. Warren | Zendy; Stela McLachlan | Zendy; Stella Trompet | Zendy; Max Moldovan | Zendy; Richard Morris | Zendy; Reecha Sofat | Zendy; Meena Kumari | Zendy; Elina Hyppönen | Zendy; Barbara J. Jefferis | Zendy; Tom R. Gaunt | Zendy; Yoav Ben–Shlomo | Zendy; Ang Zhou | Zendy; Aleksandra GentryMaharaj | Zendy; Andy Ryan | Zendy; Renée de Mutsert | Zendy; Raymond Noordam | Zendy; Mark J. Caulfield | Zendy; J. Wouter Jukema | Zendy; Bradford B. Worrall | Zendy; Patricia B. Munroe | Zendy; Usha Me | Zendy; Chris Power | Zendy; Diana Kuh | Zendy; Debbie A. Lawlor | Zendy; Steve E. Humphries | Zendy; Dennis O. MookKanamori | Zendy; Naveed Sattar | Zendy; Mika Kivimäki | Zendy; Jackie F. Price | Zendy; George Davey Smith | Zendy; Frank Dudbridge | Zendy; Aroon D. Hingorani | Zendy; Michael V. Holmes | Zendy; Juan P. Casas | Zendy

Open Access

Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus

Author(s) -

Caroline Dale,

Ghazaleh Fatemifar,

Tom Palmer,

Jon White,

David PrietoMerino,

Delilah Zabaneh,

Jorgen Engmann,

Tina Shah,

Andrew Wong,

Helen R. Warren,

Stela McLachlan,

Stella Trompet,

Max Moldovan,

Richard Morris,

Reecha Sofat,

Meena Kumari,

Elina Hyppönen,

Barbara J. Jefferis,

Tom R. Gaunt,

Yoav Ben–Shlomo,

Ang Zhou,

Aleksandra GentryMaharaj,

Andy Ryan,

Renée de Mutsert,

Raymond Noordam,

Mark J. Caulfield,

J. Wouter Jukema,

Bradford B. Worrall,

Patricia B. Munroe,

Usha Me,

Chris Power,

Diana Kuh,

Debbie A. Lawlor,

Steve E. Humphries,

Dennis O. MookKanamori,

Naveed Sattar,

Mika Kivimäki,

Jackie F. Price,

George Davey Smith,

Frank Dudbridge,

Aroon D. Hingorani,

Michael V. Holmes,

Juan P. Casas

Publication year - 2017

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.116.026560

Subject(s) - medicine , mendelian randomization , body mass index , odds ratio , diabetes mellitus , stroke (engine) , type 2 diabetes mellitus , type 2 diabetes , coronary artery disease , cardiology , waist–hip ratio , waist , endocrinology , genotype , genetics , mechanical engineering , genetic variants , gene , engineering , biology

The implications of different adiposity measures on cardiovascular disease etiology remain unclear. In this article, we quantify and contrast causal associations of central adiposity (waist-to-hip ratio adjusted for body mass index [WHRadjBMI]) and general adiposity (body mass index [BMI]) with cardiometabolic disease.

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