Effect of Long-Term Metformin and Lifestyle in the Diabetes Prevention Program and Its Outcome Study on Coronary Artery Calcium | Zendy

Ronald Goldberg | Zendy; Vanita R. Aroda | Zendy; David A. Bluemke | Zendy; Elizabeth BarrettConnor | Zendy; Matthew J. Budoff | Zendy; Jill P. Crandall | Zendy; Dana Dabelea | Zendy; Edward S. Horton | Zendy; Kieren J. Mather | Zendy; Trevor J. Orchard | Zendy; David S. Schade | Zendy; Karol E. Watson | Zendy; Marinella Temprosa | Zendy

Open Access

Effect of Long-Term Metformin and Lifestyle in the Diabetes Prevention Program and Its Outcome Study on Coronary Artery Calcium

Author(s) -

Ronald Goldberg,

Vanita R. Aroda,

David A. Bluemke,

Elizabeth BarrettConnor,

Matthew J. Budoff,

Jill P. Crandall,

Dana Dabelea,

Edward S. Horton,

Kieren J. Mather,

Trevor J. Orchard,

David S. Schade,

Karol E. Watson,

Marinella Temprosa

Publication year - 2017

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.116.025483

Subject(s) - medicine , metformin , coronary artery calcium , diabetes mellitus , calcium , term (time) , cardiology , coronary artery disease , endocrinology , physics , quantum mechanics

Despite the reduced incidence of coronary heart disease with intensive risk factor management, people with diabetes mellitus and prediabetes remain at increased coronary heart disease risk. Diabetes prevention interventions may be needed to reduce coronary heart disease risk. This approach was examined in the DPP (Diabetes Prevention Program) and the DPPOS (Diabetes Prevention Program Outcome Study), a long-term intervention study in 3234 subjects with prediabetes (mean±SD age, 64±10 years) that showed reduced diabetes risk with lifestyle and metformin compared with placebo over 3.2 years.

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