Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling | Zendy

J. Todd Belcik | Zendy; Brian P. Davidson | Zendy; Aris Xie | Zendy; Melinda Wu | Zendy; Mrinal Yadava | Zendy; Yue Qi | Zendy; Sherry Liang | Zendy; Chae Ryung Chon | Zendy; Azzdine Y. Ammi | Zendy; Joshua J. Field | Zendy; Leanne Harmann | Zendy; William M. Chilian | Zendy; Joel Linden | Zendy; Jonathan R. Lindner | Zendy

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Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling

Author(s) -

J. Todd Belcik,

Brian P. Davidson,

Aris Xie,

Melinda Wu,

Mrinal Yadava,

Yue Qi,

Sherry Liang,

Chae Ryung Chon,

Azzdine Y. Ammi,

Joshua J. Field,

Leanne Harmann,

William M. Chilian,

Joel Linden,

Jonathan R. Lindner

Publication year - 2017

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.116.024826

Subject(s) - medicine , purinergic receptor , perfusion , therapeutic ultrasound , ultrasound , pathology , receptor , radiology

Augmentation of tissue blood flow by therapeutic ultrasound is thought to rely on convective shear. Microbubble contrast agents that undergo ultrasound-mediated cavitation markedly amplify these effects. We hypothesized that purinergic signaling is responsible for shear-dependent increases in muscle perfusion during therapeutic cavitation.

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