Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming | Zendy

Tamer Mohamed | Zendy; Nicole R. Stone | Zendy; Emily Berry | Zendy; Ethan Radzinsky | Zendy; Yu Huang | Zendy; Karishma Pratt | Zendy; Yen-Sin Ang | Zendy; Pengzhi Yu | Zendy; Haixia Wang | Zendy; Shibing Tang | Zendy; Sergey Magnitsky | Zendy; Sheng Ding | Zendy; Kathryn N. Ivey | Zendy; Deepak Srivastava | Zendy

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Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming

Author(s) -

Tamer Mohamed,

Nicole R. Stone,

Emily Berry,

Ethan Radzinsky,

Yu Huang,

Karishma Pratt,

Yen-Sin Ang,

Pengzhi Yu,

Haixia Wang,

Shibing Tang,

Sergey Magnitsky,

Sheng Ding,

Kathryn N. Ivey,

Deepak Srivastava

Publication year - 2016

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.116.024692

Subject(s) - medicine , reprogramming , in vivo , in vitro , cell , biochemistry , genetics , biology

Reprogramming of cardiac fibroblasts into induced cardiomyocyte-like cells in situ represents a promising strategy for cardiac regeneration. A combination of 3 cardiac transcription factors, Gata4, Mef2c, and Tbx5 (GMT), can convert fibroblasts into induced cardiomyocyte-like cells, albeit with low efficiency in vitro.

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