Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension | Zendy

Jiwang Chen | Zendy; Justin R. Sysol | Zendy; Sunit Singla | Zendy; Shuang Zhao | Zendy; Aya Yamamura | Zendy; Daniela ValdezJasso | Zendy; Taimur Abbasi | Zendy; Krystyna M. Shioura | Zendy; Sakshi Sahni | Zendy; Vamsi Reddy | Zendy; Arvind Sridhar | Zendy; Hui Gao | Zendy; Jaime R. Torres | Zendy; Sara M. Camp | Zendy; Haiyang Tang | Zendy; Shui Qing Ye | Zendy; Suzy Comhair | Zendy; Raed A. Dweik | Zendy; Paul M. Hassoun | Zendy; Jason X.J. Yuan | Zendy; Joe G. N. Garcia | Zendy; Roberto F. Machado | Zendy

Open Access

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension

Author(s) -

Jiwang Chen,

Justin R. Sysol,

Sunit Singla,

Shuang Zhao,

Aya Yamamura,

Daniela ValdezJasso,

Taimur Abbasi,

Krystyna M. Shioura,

Sakshi Sahni,

Vamsi Reddy,

Arvind Sridhar,

Hui Gao,

Jaime R. Torres,

Sara M. Camp,

Haiyang Tang,

Shui Qing Ye,

Suzy Comhair,

Raed A. Dweik,

Paul M. Hassoun,

Jason X.J. Yuan,

Joe G. N. Garcia,

Roberto F. Machado

Publication year - 2017

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.116.024557

Subject(s) - nicotinamide phosphoribosyltransferase , medicine , pulmonary hypertension , pulmonary artery , hypoxia (environmental) , vascular smooth muscle , cancer research , vascular remodelling in the embryo , endocrinology , cardiology , nad+ kinase , pharmacology , biology , smooth muscle , enzyme , biochemistry , chemistry , organic chemistry , oxygen

Pulmonary arterial hypertension is a severe and progressive disease, a hallmark of which is pulmonary vascular remodeling. Nicotinamide phosphoribosyltransferase (NAMPT) is a cytozyme that regulates intracellular nicotinamide adenine dinucleotide levels and cellular redox state, regulates histone deacetylases, promotes cell proliferation, and inhibits apoptosis. We hypothesized that NAMPT promotes pulmonary vascular remodeling and that inhibition of NAMPT could attenuate pulmonary hypertension.

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