Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting | Zendy

Pradeep Natarajan | Zendy; Robin Young | Zendy; Nathan O. Stitziel | Zendy; Sandosh Padmanabhan | Zendy; Usman Baber | Zendy; Roxana Mehran | Zendy; Samantha Sartori | Zendy; Valentı́n Fuster | Zendy; Dermot F. Reilly | Zendy; Adam S. Butterworth | Zendy; Daniel J. Rader | Zendy; Ian Ford | Zendy; Naveed Sattar | Zendy; Sekar Kathiresan | Zendy

Open Access

Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting

Author(s) -

Pradeep Natarajan,

Robin Young,

Nathan O. Stitziel,

Sandosh Padmanabhan,

Usman Baber,

Roxana Mehran,

Samantha Sartori,

Valentı́n Fuster,

Dermot F. Reilly,

Adam S. Butterworth,

Daniel J. Rader,

Ian Ford,

Naveed Sattar,

Sekar Kathiresan

Publication year - 2017

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.116.024436

Subject(s) - medicine , primary prevention , statin , subgroup analysis , atherosclerotic cardiovascular disease , relative risk , polygenic risk score , physical therapy , disease , meta analysis , confidence interval , biochemistry , chemistry , genotype , single nucleotide polymorphism , gene

Relative risk reduction with statin therapy has been consistent across nearly all subgroups studied to date. However, in analyses of 2 randomized controlled primary prevention trials (ASCOT [Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm] and JUPITER [Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin]), statin therapy led to a greater relative risk reduction among a subgroup at high genetic risk. Here, we aimed to confirm this observation in a third primary prevention randomized controlled trial. In addition, we assessed whether those at high genetic risk had a greater burden of subclinical coronary atherosclerosis.

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