Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair | Zendy

Malte Tiburcy | Zendy; James E. Hudson | Zendy; Paul Balfanz | Zendy; Susanne F. Schlick | Zendy; Tim Meyer | Zendy; Mei-Ling Chang Liao | Zendy; Elif Levent | Zendy; Farah Raad | Zendy; Sebastian Zeidler | Zendy; Edgar Wingender | Zendy; Johannes Riegler | Zendy; Mouer Wang | Zendy; Joseph Gold | Zendy; Izhak Kehat | Zendy; Erich Wettwer | Zendy; Ursula Ravens | Zendy; Pieterjan Dierickx | Zendy; Linda W. van Laake | Zendy; MarieJosé Goumans | Zendy; Sara Khadjeh | Zendy; Karl Toischer | Zendy; Gerd Hasenfuß | Zendy; Larry A. Couture | Zendy; Andreas Unger | Zendy; Wolfgang A. Linke | Zendy; Toshiyuki Araki | Zendy; Benjamin G. Neel | Zendy; Gordon Keller | Zendy; Lior Gepstein | Zendy; Joseph C. Wu | Zendy; WolframHubertus Zimmermann | Zendy

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Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair

Author(s) -

Malte Tiburcy,

James E. Hudson,

Paul Balfanz,

Susanne F. Schlick,

Tim Meyer,

Mei-Ling Chang Liao,

Elif Levent,

Farah Raad,

Sebastian Zeidler,

Edgar Wingender,

Johannes Riegler,

Mouer Wang,

Joseph Gold,

Izhak Kehat,

Erich Wettwer,

Ursula Ravens,

Pieterjan Dierickx,

Linda W. van Laake,

MarieJosé Goumans,

Sara Khadjeh,

Karl Toischer,

Gerd Hasenfuß,

Larry A. Couture,

Andreas Unger,

Wolfgang A. Linke,

Toshiyuki Araki,

Benjamin G. Neel,

Gordon Keller,

Lior Gepstein,

Joseph C. Wu,

WolframHubertus Zimmermann

Publication year - 2017

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.116.024145

Subject(s) - induced pluripotent stem cell , heart failure , embryonic stem cell , medicine , myocyte , microbiology and biotechnology , inotrope , stem cell , biology , biochemistry , gene

Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modeling, drug screening, and heart repair. Here, we sought to advance cardiomyocyte maturation in engineered human myocardium (EHM) toward an adult phenotype under defined conditions.

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