Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest | Zendy

Sebastian Wiberg | Zendy; Christian Hassager | Zendy; Henrik Schmidt | Zendy; Jakob Hartvig Thomsen | Zendy; Martin Frydland | Zendy; Matias Greve Lindholm | Zendy; Dan Eik Høfsten | Zendy; Thomas Engstrøm | Zendy; Lars Køber | Zendy; Jacob Eifer Møller | Zendy; Jesper Kjærgaard | Zendy

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Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest

Author(s) -

Sebastian Wiberg,

Christian Hassager,

Henrik Schmidt,

Jakob Hartvig Thomsen,

Martin Frydland,

Matias Greve Lindholm,

Dan Eik Høfsten,

Thomas Engstrøm,

Lars Køber,

Jacob Eifer Møller,

Jesper Kjærgaard

Publication year - 2016

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.116.024088

Subject(s) - medicine , exenatide , targeted temperature management , return of spontaneous circulation , neuroprotection , anesthesia , placebo , diabetes mellitus , ischemia , cardiopulmonary resuscitation , pharmacology , resuscitation , type 2 diabetes , endocrinology , alternative medicine , pathology

In-hospital mortality in comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA) is ≈50%. In OHCA patients, the leading cause of death is neurological injury secondary to ischemia and reperfusion. Glucagon-like peptide-1 analogs are approved for type 2 diabetes mellitus; preclinical and clinical data have suggested their organ-protective effects in patients with ischemia and reperfusion injury. The aim of this trial was to investigate the neuroprotective effects of the glucagon-like peptide-1 analog exenatide in resuscitated OHCA patients.

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