Open AccessFemale Mice With an XY Sex Chromosome Complement Develop Severe Angiotensin II–Induced Abdominal Aortic Aneurysms
Author(s) -
Yasir Alsiraj,
Sean E. Thatcher,
Richard Charnigo,
Kuey Chen,
Eric M. Blalock,
Alan Daugherty,
Lisa A. Cassis
Publication year - 2016
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.116.023789
Subject(s) - medicine , angiotensin ii , abdominal aortic aneurysm , complement (music) , cardiology , abdominal aorta , aorta , surgery , aneurysm , gene , receptor , genetics , complementation , phenotype , biology
Abdominal aortic aneurysms (AAAs) are a deadly pathology with strong sexual dimorphism. Similar to humans, female mice exhibit far lower incidences of angiotensin II-induced AAAs than males. In addition to sex hormones, the X and Y sex chromosomes, and their unique complements of genes, may contribute to sexually dimorphic AAA pathology. Here, we defined the effect of female (XX) versus male (XY) sex chromosome complement on angiotensin II-induced AAA formation and rupture in phenotypically female mice.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom