Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke | Zendy

Andrew Bivard | Zendy; Xuya Huang | Zendy; Patrick McElduff | Zendy; Christopher Levi | Zendy; Bruce Campbell | Zendy; Bharath Kumar Cheripelli | Zendy; Dheeraj Kalladka | Zendy; Fiona Moreton | Zendy; Ian Ford | Zendy; Christopher F. Bladin | Zendy; Stephen M. Davis | Zendy; Geoffrey A. Donnan | Zendy; Keith W. Muir | Zendy; Mark Parsons | Zendy

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Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke

Author(s) -

Andrew Bivard,

Xuya Huang,

Patrick McElduff,

Christopher Levi,

Bruce Campbell,

Bharath Kumar Cheripelli,

Dheeraj Kalladka,

Fiona Moreton,

Ian Ford,

Christopher F. Bladin,

Stephen M. Davis,

Geoffrey A. Donnan,

Keith W. Muir,

Mark Parsons

Publication year - 2016

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.116.022582

Subject(s) - tenecteplase , medicine , modified rankin scale , stroke (engine) , odds ratio , fibrinolytic agent , perfusion scanning , tissue plasminogen activator , cardiology , perfusion , radiology , thrombolysis , ischemia , ischemic stroke , myocardial infarction , mechanical engineering , engineering

We pooled 2 clinical trials of tenecteplase compared with alteplase for the treatment of acute ischemic stroke, 1 that demonstrated superiority of tenecteplase and the other that showed no difference between the treatments in patient clinical outcomes. We tested the hypotheses that reperfusion therapy with tenecteplase would be superior to alteplase in improving functional outcomes in the group of patients with target mismatch as identified with advanced imaging.

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