Long-Term Risk of Atherosclerotic Cardiovascular Disease in US Adults With the Familial Hypercholesterolemia Phenotype | Zendy

Amanda M. Perak | Zendy; Hongyan Ning | Zendy; Sarah D. de Ferranti | Zendy; Holly C. Gooding | Zendy; John T. Wilkins | Zendy; Donald M. LloydJones | Zendy

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Long-Term Risk of Atherosclerotic Cardiovascular Disease in US Adults With the Familial Hypercholesterolemia Phenotype

Author(s) -

Amanda M. Perak,

Hongyan Ning,

Sarah D. de Ferranti,

Holly C. Gooding,

John T. Wilkins,

Donald M. LloydJones

Publication year - 2016

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.116.022335

Subject(s) - medicine , hazard ratio , confidence interval , proportional hazards model , familial hypercholesterolemia , myocardial infarction , epidemiology , atherosclerotic cardiovascular disease , population , cardiology , disease , cholesterol , environmental health

Heterozygous familial hypercholesterolemia (FH) affects up to 1 in 200 individuals in the United States, but atherosclerotic cardiovascular disease (ASCVD) outcomes of FH in the general US population have not been described. We therefore sought to evaluate long-term coronary heart disease (CHD) and total ASCVD risks in US adults with an FH phenotype.

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