Leukocyte-Expressed β 2 -Adrenergic Receptors Are Essential for Survival After Acute Myocardial Injury
Author(s) -
Laurel A. Grisanti,
Anna M. Gumpert,
Christopher J. Traynham,
Joshua Gorsky,
Ashley A. Repas,
Erhe Gao,
Rhonda L. Carter,
Daohai Yu,
John W. Calvert,
Andrés Pun García,
Borja Ibáñez,
Joseph E. Rabinowitz,
Walter J. Koch,
Douglas G. Tilley
Publication year - 2016
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.116.022304
Subject(s) - immune system , medicine , receptor , inflammation , cell adhesion molecule , infiltration (hvac) , transplantation , bone marrow , cell adhesion , endocrinology , pathology , cell , immunology , biology , physics , genetics , thermodynamics
Immune cell-mediated inflammation is an essential process for mounting a repair response after myocardial infarction (MI). The sympathetic nervous system is known to regulate immune system function through β-adrenergic receptors (βARs); however, their role in regulating immune cell responses to acute cardiac injury is unknown.
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