Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions | Zendy

Danish Saleheen | Zendy; Wei Zhao | Zendy; Robin Young | Zendy; Christopher P. Nelson | Zendy; Weang-Kee Ho | Zendy; Jane F. Ferguson | Zendy; Asif Rasheed | Zendy; Kristy Ou | Zendy; Sylvia Nürnberg | Zendy; Robert C. Bauer | Zendy; Anuj Goel | Zendy; Ron Do | Zendy; Alexandre F.R. Stewart | Zendy; Jaana Hartiala | Zendy; Weihua Zhang | Zendy; Guðmar Þorleifsson | Zendy; Rona J. Strawbridge | Zendy; Juha Sinisalo | Zendy; Stavroula Kai | Zendy; Sanaz Sedaghat | Zendy; Eirini Marouli | Zendy; Kati Kristiansson | Zendy; Robert A. Scott | Zendy; Dominique Gauguier | Zendy; Svati H. Shah | Zendy; Albert V. Smith | Zendy; Natalie Van Zuydam | Zendy; Amanda J. Cox | Zendy; Christina Willenborg | Zendy; Thorsten Kessler | Zendy; Lingyao Zeng | Zendy; Michael A. Province | Zendy; Andrea Ganna | Zendy; Lars Lind | Zendy; Nancy L. Pedersen | Zendy; Charles C. White | Zendy; Anni Joensuu | Zendy; Marcus E. Kleber | Zendy; Alistair S. Hall | Zendy; Winfried März | Zendy; Veikko Salomaa | Zendy; Christopher J. O’Donnell | Zendy; Erik Ingelsson | Zendy; Mary F. Feitosa | Zendy; Jeanette Erdmann | Zendy; Donald W. Bowden | Zendy; Nicholette D. Palmer | Zendy; Vilmundur Guðnason | Zendy; Ulf dé Fairé | Zendy; Pierre Zalloua | Zendy; Nicholas J. Wareham | Zendy; John R. Thompson | Zendy; Kari Kuulasmaa | Zendy; George Dedoussis | Zendy; Markus Perola | Zendy; Abbas Dehghan | Zendy; John C. Chambers | Zendy; Jaspal S. Kooner | Zendy; Hooman Allayee | Zendy; Panos Deloukas | Zendy; Ruth McPherson | Zendy; Kári Stéfansson | Zendy; Heribert Schunkert | Zendy; Sekar Kathiresan | Zendy; Martin Farrall | Zendy; Philippe M. Frossard | Zendy; Daniel J. Rader | Zendy; Nilesh J. Samani | Zendy; Muredach P. Reilly | Zendy

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Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

Author(s) -

Danish Saleheen,

Wei Zhao,

Robin Young,

Christopher P. Nelson,

Weang-Kee Ho,

Jane F. Ferguson,

Asif Rasheed,

Kristy Ou,

Sylvia Nürnberg,

Robert C. Bauer,

Anuj Goel,

Ron Do,

Alexandre F.R. Stewart,

Jaana Hartiala,

Weihua Zhang,

Guðmar Þorleifsson,

Rona J. Strawbridge,

Juha Sinisalo,

Stavroula Kai,

Sanaz Sedaghat,

Eirini Marouli,

Kati Kristiansson,

Robert A. Scott,

Dominique Gauguier,

Svati H. Shah,

Albert V. Smith,

Natalie Van Zuydam,

Amanda J. Cox,

Christina Willenborg,

Thorsten Kessler,

Lingyao Zeng,

Michael A. Province,

Andrea Ganna,

Lars Lind,

Nancy L. Pedersen,

Charles C. White,

Anni Joensuu,

Marcus E. Kleber,

Alistair S. Hall,

Winfried März,

Veikko Salomaa,

Christopher J. O’Donnell,

Erik Ingelsson,

Mary F. Feitosa,

Jeanette Erdmann,

Donald W. Bowden,

Nicholette D. Palmer,

Vilmundur Guðnason,

Ulf dé Fairé,

Pierre Zalloua,

Nicholas J. Wareham,

John R. Thompson,

Kari Kuulasmaa,

George Dedoussis,

Markus Perola,

Abbas Dehghan,

John C. Chambers,

Jaspal S. Kooner,

Hooman Allayee,

Panos Deloukas,

Ruth McPherson,

Kári Stéfansson,

Heribert Schunkert,

Sekar Kathiresan,

Martin Farrall,

Philippe M. Frossard,

Daniel J. Rader,

Nilesh J. Samani,

Muredach P. Reilly

Publication year - 2017

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.116.022069

Subject(s) - allele , medicine , locus (genetics) , gene , genetics , genotype , etiology , coronary artery disease , bonferroni correction , biology , statistics , mathematics

Common diseases such as coronary heart disease (CHD) are complex in etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent role. However, gene-lifestyle interactions for CHD have been difficult to identify. Here, we investigate interaction of smoking behavior, a potent lifestyle factor, with genotypes that have been shown to associate with CHD risk.

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