Peptidomimetic Targeting of Ca v β2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac Function | Zendy

Francesca Rusconi | Zendy; Paola Ceriotti | Zendy; Michele Miragoli | Zendy; Pierluigi Carullo | Zendy; Nicolò Salvarani | Zendy; Marcella Rocchetti | Zendy; Elisa Di Pasquale | Zendy; Stefano Rossi | Zendy; Maddalena Tessari | Zendy; Silvia Caprari | Zendy; Magali Cazade | Zendy; Paolo Kunderfranco | Zendy; Jean Chemin | Zendy; MarieLouise Bang | Zendy; Fabio Polticelli | Zendy; Antonio Zaza | Zendy; Giuseppe Faggian | Zendy; Gianluigi Condorelli | Zendy; Daniele Catalucci | Zendy

Open Access

Peptidomimetic Targeting of Ca _v β2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac Function

Author(s) -

Francesca Rusconi,

Paola Ceriotti,

Michele Miragoli,

Pierluigi Carullo,

Nicolò Salvarani,

Marcella Rocchetti,

Elisa Di Pasquale,

Stefano Rossi,

Maddalena Tessari,

Silvia Caprari,

Magali Cazade,

Paolo Kunderfranco,

Jean Chemin,

MarieLouise Bang,

Fabio Polticelli,

Antonio Zaza,

Giuseppe Faggian,

Gianluigi Condorelli,

Daniele Catalucci

Publication year - 2016

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.116.021347

Subject(s) - medicine , calcium channel , calcium , function (biology) , peptidomimetic , neuroscience , microbiology and biotechnology , biochemistry , biology , peptide , chemistry

L-type calcium channels (LTCCs) play important roles in regulating cardiomyocyte physiology, which is governed by appropriate LTCC trafficking to and density at the cell surface. Factors influencing the expression, half-life, subcellular trafficking, and gating of LTCCs are therefore critically involved in conditions of cardiac physiology and disease.

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