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Baudrand et al1 reported that statin use was associated with lower plasma aldosterone levels and urinary aldosterone excretion in nonrandomized studies of hypertensive and diabetic subjects, both in the basal state and during stimulation by angiotensin II infusion or by a low sodium diet. They also reported that 10 μmol/L statins, a concentration that far exceeds peak plasma statin concentrations in patients, reduced the aldosterone secretory response of rat zona glomerulosa cells to angiotensin II and to potassium stimulation in vitro, and proposed that statins might reduce plasma aldosterone levels …

Letter by Campbell Regarding Article, “Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects”