Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension | Zendy

Cathelijne E. van der Bruggen | Zendy; Chris Happé | Zendy; Peter Dorfmüller | Zendy; Pia Trip | Zendy; Onno A. Spruijt | Zendy; Nina Rol | Zendy; Femke P. M. Hoevenaars | Zendy; Arjan C. Houweling | Zendy; Barbara Girerd | Zendy; J. Tim Marcus | Zendy; Olaf Mercier | Zendy; Marc Humbert | Zendy; M. Louis Handoko | Zendy; Jolanda van der Velden | Zendy; Anton Vonk Noordegraaf | Zendy; Harm Jan Bogaard | Zendy; MarieJosé Goumans | Zendy; Frances S. de Man | Zendy

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Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension

Author(s) -

Cathelijne E. van der Bruggen,

Chris Happé,

Peter Dorfmüller,

Pia Trip,

Onno A. Spruijt,

Nina Rol,

Femke P. M. Hoevenaars,

Arjan C. Houweling,

Barbara Girerd,

J. Tim Marcus,

Olaf Mercier,

Marc Humbert,

M. Louis Handoko,

Jolanda van der Velden,

Anton Vonk Noordegraaf,

Harm Jan Bogaard,

MarieJosé Goumans,

Frances S. de Man

Publication year - 2016

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.020696

Subject(s) - medicine , bone morphogenetic protein , bone morphogenetic protein receptor , bmpr2 , pulmonary hypertension , cardiology , receptor , mutation , endocrinology , genetics , gene , biology

The effect of a mutation in the bone morphogenetic protein receptor 2 (BMPR2) gene on right ventricular (RV) pressure overload in patients with pulmonary arterial hypertension is unknown. Therefore, we investigated RV function in patients who have pulmonary arterial hypertension with and without the BMPR2 mutation by combining in vivo measurements with molecular and histological analysis of human RV and left ventricular tissue.

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