Higher Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability Is Associated With Lower Cognitive Performance, Lower Cerebral Blood Flow, and Greater White Matter Hyperintensity Load in Older Subjects | Zendy

Roelof A.J. Smit | Zendy; Stella Trompet | Zendy; Behnam Sabayan | Zendy; Saskia le Cessie | Zendy; Jeroen van der Grond | Zendy; Mark A. van Buchem | Zendy; Anton J.M. de Craen | Zendy; J. Wouter Jukema | Zendy

Open Access

Higher Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability Is Associated With Lower Cognitive Performance, Lower Cerebral Blood Flow, and Greater White Matter Hyperintensity Load in Older Subjects

Author(s) -

Roelof A.J. Smit,

Stella Trompet,

Behnam Sabayan,

Saskia le Cessie,

Jeroen van der Grond,

Mark A. van Buchem,

Anton J.M. de Craen,

J. Wouter Jukema

Publication year - 2016

Publication title -

circulation

Language(s) - English

Resource type - Journals

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.020627

Subject(s) - medicine , pravastatin , hyperintensity , statin , cardiology , cerebral blood flow , magnetic resonance imaging , effects of sleep deprivation on cognitive performance , cognition , cognitive decline , endocrinology , cholesterol , dementia , psychiatry , radiology , disease

Recently, it was shown that intraindividual variation in low-density lipoprotein cholesterol (LDL-C) predicts both cerebrovascular and cardiovascular events. We aimed to examine whether this extends to cognitive function and examined possible pathways using a magnetic resonance imaging substudy.

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