Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure | Zendy

Haipeng Sun | Zendy; Kristine C. Olson | Zendy; Chen Gao | Zendy; Domenick A. Prosdocimo | Zendy; Meiyi Zhou | Zendy; Wang Zh | Zendy; Darwin Jeyaraj | Zendy; Ji-Youn Youn | Zendy; Shuxun Ren | Zendy; Yunxia Liu | Zendy; Christoph Rau | Zendy; Svati H. Shah | Zendy; Olga Ilkayeva | Zendy; W.J. Gui | Zendy; Noelle S. William | Zendy; Richard Wynn | Zendy; Christopher B. Newgard | Zendy; Hua Cai | Zendy; Xinshu Xiao | Zendy; David Chuang | Zendy; P. Christian Schulze | Zendy; Christopher J. Lynch | Zendy; Mukesh K. Jain | Zendy; Yibin Wang | Zendy

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Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure

Author(s) -

Haipeng Sun,

Kristine C. Olson,

Chen Gao,

Domenick A. Prosdocimo,

Meiyi Zhou,

Wang Zh,

Darwin Jeyaraj,

Ji-Youn Youn,

Shuxun Ren,

Yunxia Liu,

Christoph Rau,

Svati H. Shah,

Olga Ilkayeva,

W.J. Gui,

Noelle S. William,

Richard Wynn,

Christopher B. Newgard,

Hua Cai,

Xinshu Xiao,

David Chuang,

P. Christian Schulze,

Christopher J. Lynch,

Mukesh K. Jain,

Yibin Wang

Publication year - 2016

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.020226

Subject(s) - catabolism , pressure overload , branched chain amino acid , krüppel , heart failure , mitochondrion , amino acid , transcription factor , biochemistry , medicine , endocrinology , metabolism , biology , gene , leucine , cardiac hypertrophy

Although metabolic reprogramming is critical in the pathogenesis of heart failure, studies to date have focused principally on fatty acid and glucose metabolism. Contribution of amino acid metabolic regulation in the disease remains understudied.

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