Open AccessGenotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy
Author(s) -
Adam Helms,
Francisco Alvarado,
Jaime Yob,
Vi T. Tang,
Francis D. Pagani,
Mark W. Russell,
Héctor H. Valdivia,
Sharlene M. Day
Publication year - 2016
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.115.020086
Subject(s) - phospholamban , ryanodine receptor , calcineurin , medicine , endocrinology , ryanodine receptor 2 , calsequestrin , calcium , sarcomere , biology , microbiology and biotechnology , myocyte , transplantation
Aberrant calcium signaling may contribute to arrhythmias and adverse remodeling in hypertrophic cardiomyopathy (HCM). Mutations in sarcomere genes may distinctly alter calcium handling pathways.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom