Elevated Angiopoietin-2 Level in Patients With Continuous-Flow Left Ventricular Assist Devices Leads to Altered Angiogenesis and Is Associated With Higher Nonsurgical Bleeding | Zendy

Corey E. Tabit | Zendy; Phetcharat Chen | Zendy; Gene Kim | Zendy; Savitri Fedson | Zendy; G. Sayer | Zendy; Mitchell J. Coplan | Zendy; Valluvan Jeevanandam | Zendy; Nir Uriel | Zendy; James K. Liao | Zendy

Open Access

Elevated Angiopoietin-2 Level in Patients With Continuous-Flow Left Ventricular Assist Devices Leads to Altered Angiogenesis and Is Associated With Higher Nonsurgical Bleeding

Author(s) -

Corey E. Tabit,

Phetcharat Chen,

Gene Kim,

Savitri Fedson,

G. Sayer,

Mitchell J. Coplan,

Valluvan Jeevanandam,

Nir Uriel,

James K. Liao

Publication year - 2016

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.019692

Subject(s) - medicine , angiogenesis , angiopoietin , heart failure , ventricular assist device , cardiology , angiopoietin 2 , angiopoietin receptor , heart transplantation , thrombin , transplantation , vascular endothelial growth factor , endocrinology , platelet , vegf receptors

Nonsurgical bleeding is the most common adverse event in patients with continuous-flow left ventricular assist devices (LVADs) and is caused by arteriovenous malformations. We hypothesized that deregulation of an angiogenic factor, angiopoietin-2 (Ang-2), in patients with LVADs leads to increased angiogenesis and higher nonsurgical bleeding.

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