Acute Limb Ischemia and Outcomes With Vorapaxar in Patients With Peripheral Artery Disease | Zendy

Marc P. Bonaca | Zendy; J. Antonio Gutierrez | Zendy; Mark A. Creager | Zendy; Benjamin M. Scirica | Zendy; Jeffrey W. Olin | Zendy; Sabina A. Murphy | Zendy; Eugene Braunwald | Zendy; David A. Morrow | Zendy

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Acute Limb Ischemia and Outcomes With Vorapaxar in Patients With Peripheral Artery Disease

Author(s) -

Marc P. Bonaca,

J. Antonio Gutierrez,

Mark A. Creager,

Benjamin M. Scirica,

Jeffrey W. Olin,

Sabina A. Murphy,

Eugene Braunwald,

David A. Morrow

Publication year - 2016

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.019355

Subject(s) - medicine , stroke (engine) , hazard ratio , myocardial infarction , cardiology , thrombosis , revascularization , amputation , population , thrombolysis , placebo , surgery , confidence interval , pathology , mechanical engineering , alternative medicine , environmental health , engineering

Patients with peripheral artery disease (PAD) are at heightened risk of acute limb ischemia (ALI), a morbid event that may result in limb loss. We investigated the causes, sequelae, and predictors of ALI in a contemporary population with symptomatic PAD and whether protease-activated receptor 1 antagonism with vorapaxar reduced ALI overall and by type.

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