Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension | Zendy

Evan L. Brittain | Zendy; Megha Talati | Zendy; Joshua P. Fessel | Zendy; He Zhu | Zendy; Niki Penner | Zendy; M. Wade Calcutt | Zendy; James West | Zendy; Mitch Funke | Zendy; Gregory D. Lewis | Zendy; Robert E. Gerszten | Zendy; Rizwan Hamid | Zendy; Meredith E. Pugh | Zendy; Eric D. Austin | Zendy; John H. Newman | Zendy; Anna R. Hemnes | Zendy

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Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension

Author(s) -

Evan L. Brittain,

Megha Talati,

Joshua P. Fessel,

He Zhu,

Niki Penner,

M. Wade Calcutt,

James West,

Mitch Funke,

Gregory D. Lewis,

Robert E. Gerszten,

Rizwan Hamid,

Meredith E. Pugh,

Eric D. Austin,

John H. Newman,

Anna R. Hemnes

Publication year - 2016

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.019351

Subject(s) - lipotoxicity , medicine , endocrinology , triglyceride , fatty acid , fatty acid metabolism , steatosis , in vivo , metabolism , cholesterol , chemistry , biology , biochemistry , insulin resistance , insulin , microbiology and biotechnology

The mechanisms of right ventricular (RV) failure in pulmonary arterial hypertension (PAH) are poorly understood. Abnormalities in fatty acid (FA) metabolism have been described in experimental models of PAH, but systemic and myocardial FA metabolism has not been studied in human PAH.

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