Open AccessSIRT3–AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction
Author(s) -
YenChun Lai,
Diana M. Tabima,
John J. Dubé,
Kara S. Hughan,
Rebecca Vanderpool,
Dmitry A. Goncharov,
Claudette M. St. Croix,
Adolfo GarcíaOcaña,
Elena A. Goncharova,
Stevan P. Tofovic,
Ana L. Mora,
Mark T. Gladwin
Publication year - 2016
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.115.018935
Subject(s) - medicine , heart failure with preserved ejection fraction , metformin , ampk , endocrinology , heart failure , sirt3 , amp activated protein kinase , pulmonary hypertension , metabolic syndrome , skeletal muscle , insulin resistance , protein kinase a , pharmacology , ejection fraction , diabetes mellitus , sirtuin , insulin , kinase , biochemistry , chemistry , acetylation , gene
Pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF) is an increasingly recognized clinical complication of metabolic syndrome. No adequate animal model of PH-HFpEF is available, and no effective therapies have been identified to date. A recent study suggested that dietary nitrate improves insulin resistance in endothelial nitric oxide synthase null mice, and multiple studies have reported that both nitrate and its active metabolite, nitrite, have therapeutic activity in preclinical models of pulmonary hypertension.
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