Letter by Belge et al Regarding Article, “Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Models” | Zendy

Catharina Belge | Zendy; Rozenn Quarck | Zendy; Marion Delcroix | Zendy

Open Access

Letter by Belge et al Regarding Article, “Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Models”

Author(s) -

Catharina Belge,

Rozenn Quarck,

Marion Delcroix

Publication year - 2016

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.018683

Subject(s) - medicine , surgery

We read with great interest the article by Perros et al,1 which reported mitomycin C (MMC)–induced pulmonary veno-occlusive disease (PVOD) in patients displaying anal squamous cancer and in a rat preclinical model.We would like to share our experience with 2 more patients with pulmonary hypertension related to MMC exposure who did not show radiological evidence of PVOD. It concerns a 59-year-old man with an anal carcinoma and a 53-year-old woman with an anorectal spinocellular carcinoma. Both were treated by radiochemotherapy (MMC plus 5-fluoruracil) and developed dyspnea on exertion within 4 years and 1 year. Echocardiogram showed increased systolic pulmonary arterial pressure, right ventricular dilatation …

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