Letter by Poullis Regarding Article, “Efficacy of Long-Term β-Blocker Therapy for Secondary Prevention of Long-Term Outcomes After Coronary Artery Bypass Grafting Surgery” | Zendy

Michael Poullis | Zendy

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Letter by Poullis Regarding Article, “Efficacy of Long-Term β-Blocker Therapy for Secondary Prevention of Long-Term Outcomes After Coronary Artery Bypass Grafting Surgery”

Author(s) -

Michael Poullis

Publication year - 2016

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.018190

Subject(s) - medicine , coronary artery bypass surgery , artery , myocardial infarction , cohort , cardiology , bypass grafting , unstable angina , incidence (geometry) , dyslipidemia , surgery , disease , physics , optics

Zhang et al1 present important information with regard to β-blocker therapy and long-term outcomes in patients who have undergone coronary artery bypass graft surgery. Despite a meticulous analysis, a number of issues exist.Interestingly, in univariate analysis of patients with prior myocardial infarction, inconsistent use was significantly associated with a worse long-term survival compared with never and always users, implying that β-receptor upregulation, supersensitivity, and proarrhythmic potential are possible underlying mechanisms of their study findings rather than …

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