Response to Letter Regarding Article “Transdifferentiation of Human Fibroblasts to Endothelial Cells: Role of Innate Immunity” | Zendy

John P. Cooke | Zendy; Shu Meng | Zendy; Wing Tak Wong | Zendy; Nazish Sayed | Zendy; Frank Ospino | Zendy; Jieun Lee | Zendy; Arshi Jha | Zendy; Phillip J. Dexheimer | Zendy; Bruce J. Aronow | Zendy

Open Access

Response to Letter Regarding Article “Transdifferentiation of Human Fibroblasts to Endothelial Cells: Role of Innate Immunity”

Author(s) -

John P. Cooke,

Shu Meng,

Wing Tak Wong,

Nazish Sayed,

Frank Ospino,

Jieun Lee,

Arshi Jha,

Phillip J. Dexheimer,

Bruce J. Aronow

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.016792

Subject(s) - transdifferentiation , medicine , regeneration (biology) , library science , gerontology , stem cell , biology , microbiology and biotechnology , computer science

We thank Drs Li and Hao for their thoughtful comments on our recent article on the role of innate immunity in transdifferentiation of human fibroblasts to endothelial cells.1 They correctly state that the epigenetic landscape is different from one somatic cell to another and that the determinants of that epigenetic landscape (such as small RNAs, transcriptional factors, and chromatin modifiers) also differ from one somatic cell to another. Accordingly, they pose an excellent question: Because of the known differences between somatic cells in their epigenetic landscape and …

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