Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability | Zendy

Julie Wang | Zendy; Anna Uryga | Zendy; Johannes Reinhold | Zendy; Nichola Figg | Zendy; Lauren Baker | Zendy; Alison Finigan | Zendy; Kelly Gray | Zendy; Sheetal Kumar | Zendy; Murray C.H. Clarke | Zendy; Martin R. Bennett | Zendy

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Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability

Author(s) -

Julie Wang,

Anna Uryga,

Johannes Reinhold,

Nichola Figg,

Lauren Baker,

Alison Finigan,

Kelly Gray,

Sheetal Kumar,

Murray C.H. Clarke,

Martin R. Bennett

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.016457

Subject(s) - senescence , telomere , vascular smooth muscle , dna damage , microbiology and biotechnology , biology , medicine , endocrinology , dna , biochemistry , smooth muscle

Although vascular smooth muscle cell (VSMC) proliferation is implicated in atherogenesis, VSMCs in advanced plaques and cultured from plaques show evidence of VSMC senescence and DNA damage. In particular, plaque VSMCs show shortening of telomeres, which can directly induce senescence. Senescence can have multiple effects on plaque development and morphology; however, the consequences of VSMC senescence or the mechanisms underlying VSMC senescence in atherosclerosis are mostly unknown.

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