Downregulation of MicroRNA-126 Contributes to the Failing Right Ventricle in Pulmonary Arterial Hypertension | Zendy

François Potus | Zendy; Grégoire Ruffenach | Zendy; Abdellaziz Dahou | Zendy; Christophe Thébault | Zendy; Sandra BreuilsBonnet | Zendy; Ève Tremblay | Zendy; Valérie Nadeau | Zendy; Renée Paradis | Zendy; Colin Graydon | Zendy; Ryan L. Wong | Zendy; Ian Johnson | Zendy; Roxane Paulin | Zendy; Annie C. Lajoie | Zendy; Jean Perron | Zendy; Éric Charbonneau | Zendy; Philippe Joubert | Zendy; Philippe Pîbarot | Zendy; Evangelos D. Michelakis | Zendy; Steeve Provencher | Zendy; Sébastien Bonnet | Zendy

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Downregulation of MicroRNA-126 Contributes to the Failing Right Ventricle in Pulmonary Arterial Hypertension

Author(s) -

François Potus,

Grégoire Ruffenach,

Abdellaziz Dahou,

Christophe Thébault,

Sandra BreuilsBonnet,

Ève Tremblay,

Valérie Nadeau,

Renée Paradis,

Colin Graydon,

Ryan L. Wong,

Ian Johnson,

Roxane Paulin,

Annie C. Lajoie,

Jean Perron,

Éric Charbonneau,

Philippe Joubert,

Philippe Pîbarot,

Evangelos D. Michelakis,

Steeve Provencher,

Sébastien Bonnet

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.016382

Subject(s) - downregulation and upregulation , medicine , angiogenesis , cd31 , heart failure , vascular endothelial growth factor , mapk/erk pathway , pulmonary hypertension , vascular endothelial growth factor a , neovascularization , endocrinology , cardiology , cancer research , kinase , biology , microbiology and biotechnology , vegf receptors , biochemistry , gene

Right ventricular (RV) failure is the most important factor of both morbidity and mortality in pulmonary arterial hypertension (PAH). However, the underlying mechanisms resulting in the failed RV in PAH remain unknown. There is growing evidence that angiogenesis and microRNAs are involved in PAH-associated RV failure. We hypothesized that microRNA-126 (miR-126) downregulation decreases microvessel density and promotes the transition from a compensated to a decompensated RV in PAH.

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