Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y -PCSK9 Hypercholesterolemic Minipigs | Zendy

Ryan M. Pedrigi | Zendy; Christian Bo Poulsen | Zendy; Vikram V. Mehta | Zendy; Niels Ramsing Holm | Zendy; Nilesh Pareek | Zendy; Anouk L. Post | Zendy; İsmail Doğu Kılıç | Zendy; Winston Banya | Zendy; Gianni Dall’Ara | Zendy; Alessio Mattesini | Zendy; Martin M. Bjørklund | Zendy; Niels Peter Andersen | Zendy; Anna K. Grøndal | Zendy; Enrico Petretto | Zendy; Nicolas Foin | Zendy; Justin E. Davies | Zendy; Carlo Di Mario | Zendy; Jacob Fog Bentzon | Zendy; Hans Erik Bøtker | Zendy; Erling Falk | Zendy; Rob Krams | Zendy; Ranil de Silva | Zendy

Open Access

Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y -PCSK9 Hypercholesterolemic Minipigs

Author(s) -

Ryan M. Pedrigi,

Christian Bo Poulsen,

Vikram V. Mehta,

Niels Ramsing Holm,

Nilesh Pareek,

Anouk L. Post,

İsmail Doğu Kılıç,

Winston Banya,

Gianni Dall’Ara,

Alessio Mattesini,

Martin M. Bjørklund,

Niels Peter Andersen,

Anna K. Grøndal,

Enrico Petretto,

Nicolas Foin,

Justin E. Davies,

Carlo Di Mario,

Jacob Fog Bentzon,

Hans Erik Bøtker,

Erling Falk,

Rob Krams,

Ranil de Silva

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.016270

Subject(s) - medicine , shear stress , cardiology , stenosis , artery , composite material , materials science

Although disturbed flow is thought to play a central role in the development of advanced coronary atherosclerotic plaques, no causal relationship has been established. We evaluated whether inducing disturbed flow would cause the development of advanced coronary plaques, including thin cap fibroatheroma.

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