Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II–Associated Pulmonary Arterial Hypertension Through MicroRNA-29–Mediated Modulation of Cellular Metabolism | Zendy

Xinping Chen | Zendy; Megha Talati | Zendy; Joshua P. Fessel | Zendy; Anna R. Hemnes | Zendy; Santhi Gladson | Zendy; Jaketa L. French | Zendy; Sheila Shay | Zendy; Aaron W. Trammell | Zendy; John A. Phillips | Zendy; Rizwan Hamid | Zendy; Joy D. Cogan | Zendy; Elliott P. Dawson | Zendy; Kristie E. Womble | Zendy; Lora K. Hedges | Zendy; Elizabeth G Martinez | Zendy; Lisa Wheeler | Zendy; James E. Loyd | Zendy; Susan J. Majka | Zendy; James West | Zendy; Eric D. Austin | Zendy

Open Access

Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II–Associated Pulmonary Arterial Hypertension Through MicroRNA-29–Mediated Modulation of Cellular Metabolism

Author(s) -

Xinping Chen,

Megha Talati,

Joshua P. Fessel,

Anna R. Hemnes,

Santhi Gladson,

Jaketa L. French,

Sheila Shay,

Aaron W. Trammell,

John A. Phillips,

Rizwan Hamid,

Joy D. Cogan,

Elliott P. Dawson,

Kristie E. Womble,

Lora K. Hedges,

Elizabeth G Martinez,

Lisa Wheeler,

James E. Loyd,

Susan J. Majka,

James West,

Eric D. Austin

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.016133

Subject(s) - medicine , estrogen , metabolite , selective estrogen receptor modulator , microrna , endocrinology , estrogen receptor , bone morphogenetic protein receptor , pulmonary hypertension , bone morphogenetic protein , bone remodeling , cardiology , pharmacology , biochemistry , gene , biology , cancer , breast cancer

Pulmonary arterial hypertension (PAH) is a proliferative disease of the pulmonary vasculature that preferentially affects women. Estrogens such as the metabolite 16α-hydroxyestrone (16αOHE) may contribute to PAH pathogenesis, and alterations in cellular energy metabolism associate with PAH. We hypothesized that 16αOHE promotes heritable PAH (HPAH) via microRNA-29 (miR-29) family upregulation and that antagonism of miR-29 would attenuate pulmonary hypertension in transgenic mouse models of Bmpr2 mutation.

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