Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood–Brain Barrier Integrity and Central Nervous System Homeostasis | Zendy

Khiem A. Tran | Zendy; Xianming Zhang | Zendy; Dan Predescu | Zendy; Xiaojia Huang | Zendy; Roberto F. Machado | Zendy; Joachim R. Göthert | Zendy; Asrar B. Malik | Zendy; Tibor ValyiNagy | Zendy; YouYang Zhao | Zendy

Open Access

Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood–Brain Barrier Integrity and Central Nervous System Homeostasis

Author(s) -

Khiem A. Tran,

Xianming Zhang,

Dan Predescu,

Xiaojia Huang,

Roberto F. Machado,

Joachim R. Göthert,

Asrar B. Malik,

Tibor ValyiNagy,

YouYang Zhao

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.015982

Subject(s) - medicine , blood–brain barrier , central nervous system , homeostasis , signal transduction , neuroscience , microbiology and biotechnology , biology

The blood-brain barrier (BBB) formed by brain endothelial cells interconnected by tight junctions is essential for the homeostasis of the central nervous system. Although studies have shown the importance of various signaling molecules in BBB formation during development, little is known about the molecular basis regulating the integrity of the adult BBB.

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