Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors | Zendy

Gianluigi Pironti | Zendy; Ryan T. Strachan | Zendy; Dennis Abraham | Zendy; Samuel Mon-Wei Yu | Zendy; Minyong Chen | Zendy; Wei Chen | Zendy; Kenji Hanada | Zendy; Lan Mao | Zendy; Lewis J. Watson | Zendy; Howard A. Rockman | Zendy

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Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors

Author(s) -

Gianluigi Pironti,

Ryan T. Strachan,

Dennis Abraham,

Samuel Mon-Wei Yu,

Minyong Chen,

Wei Chen,

Kenji Hanada,

Lan Mao,

Lewis J. Watson,

Howard A. Rockman

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.015687

Subject(s) - microvesicles , pressure overload , angiotensin ii , receptor , microbiology and biotechnology , exosome , medicine , endocrinology , biology , heart failure , biochemistry , microrna , cardiac hypertrophy , gene

Whether biomechanical force on the heart can induce exosome secretion to modulate cardiovascular function is not known. We investigated the secretion and activity of exosomes containing a key receptor in cardiovascular function, the angiotensin II type I receptor (AT1R).

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