Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice | Zendy

Zhuofeng Lin | Zendy; Xuebo Pan | Zendy; Fan Wu | Zendy; Dewei Ye | Zendy; Yi Zhang | Zendy; Yu Wang | Zendy; Leigang Jin | Zendy; Qizhou Lian | Zendy; Yü Huang | Zendy; Hong Ding | Zendy; Chris R. Triggle | Zendy; Kai Wang | Zendy; Xiaokun Li | Zendy; Aimin Xu | Zendy

Open Access

Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice

Author(s) -

Zhuofeng Lin,

Xuebo Pan,

Fan Wu,

Dewei Ye,

Yi Zhang,

Yu Wang,

Leigang Jin,

Qizhou Lian,

Yü Huang,

Hong Ding,

Chris R. Triggle,

Kai Wang,

Xiaokun Li,

Aimin Xu

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.015308

Subject(s) - fgf21 , medicine , endocrinology , adiponectin , apolipoprotein b , neointima , adipose tissue , ldl receptor , fibroblast growth factor , biology , lipoprotein , cholesterol , receptor , insulin resistance , insulin , stent , restenosis

Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It acts as a key downstream target of both peroxisome proliferator-activated receptor α and γ, the agonists of which have been used for lipid lowering and insulin sensitization, respectively. However, the role of FGF21 in the cardiovascular system remains elusive.

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