Mitomycin-Induced Pulmonary Veno-Occlusive Disease | Zendy

Frédéric Perros | Zendy; Sven Günther | Zendy; Benoît Ranchoux | Zendy; Laurent Godinas | Zendy; Fabrice Antigny | Zendy; MarieCamille Chaumais | Zendy; Peter Dorfmüller | Zendy; Aurélie Hautefort | Zendy; Nicolas Raymond | Zendy; Laurent Savale | Zendy; Xavier Jaïs | Zendy; Barbara Girerd | Zendy; Vincent Cottin | Zendy; Olivier Sitbon | Zendy; Gérald Simonneau | Zendy; Marc Humbert | Zendy; David Montani | Zendy

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Mitomycin-Induced Pulmonary Veno-Occlusive Disease

Author(s) -

Frédéric Perros,

Sven Günther,

Benoît Ranchoux,

Laurent Godinas,

Fabrice Antigny,

MarieCamille Chaumais,

Peter Dorfmüller,

Aurélie Hautefort,

Nicolas Raymond,

Laurent Savale,

Xavier Jaïs,

Barbara Girerd,

Vincent Cottin,

Olivier Sitbon,

Gérald Simonneau,

Marc Humbert,

David Montani

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.115.014207

Subject(s) - medicine , pulmonary veno occlusive disease , mitomycin c , cardiology , hepatic veno occlusive disease , disease , surgery , hematopoietic stem cell transplantation

Pulmonary veno-occlusive disease (PVOD) is an uncommon form of pulmonary hypertension characterized by the obstruction of small pulmonary veins and a dismal prognosis. PVOD may be sporadic or heritable because of biallelic mutations of the EIF2AK4 gene coding for GCN2. Isolated case reports suggest that chemotherapy may be a risk factor for PVOD.

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