Microfluidic Single-Cell Analysis of Transplanted Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes After Acute Myocardial Infarction | Zendy

Sang-Ging Ong | Zendy; Bruno Hüber | Zendy; Won Hee Lee | Zendy; Kazuki Kodo | Zendy; Antje Ebert | Zendy; Yu Ma | Zendy; Patricia K. Nguyen | Zendy; Sebastian Diecke | Zendy; Wen-Yi Chen | Zendy; Joseph C. Wu | Zendy

Open Access

Microfluidic Single-Cell Analysis of Transplanted Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes After Acute Myocardial Infarction

Author(s) -

Sang-Ging Ong,

Bruno Hüber,

Won Hee Lee,

Kazuki Kodo,

Antje Ebert,

Yu Ma,

Patricia K. Nguyen,

Sebastian Diecke,

Wen-Yi Chen,

Joseph C. Wu

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.015231

Subject(s) - induced pluripotent stem cell , medicine , transplantation , stem cell , myocardial infarction , bioluminescence imaging , paracrine signalling , stem cell therapy , cancer research , microbiology and biotechnology , pathology , cardiology , cell culture , embryonic stem cell , luciferase , biology , genetics , gene , transfection , biochemistry , receptor

Human induced pluripotent stem cells (iPSCs) are attractive candidates for therapeutic use, with the potential to replace deficient cells and to improve functional recovery in injury or disease settings. Here, we test the hypothesis that human iPSC-derived cardiomyocytes (iPSC-CMs) can secrete cytokines as a molecular basis to attenuate adverse cardiac remodeling after myocardial infarction.

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